ELECTROSPUN PVP/CA NANOFIBER LOADED PERICARP MANGOSTEEN EXTRACT FOR WOUND DRESSING APPLICATION

• Main Author: HARTATI (NIM : 20216008), SRI
• Format: Theses
• Language: Indonesia
• Subjects: Fisika
• Online Access: https://digilib.itb.ac.id/gdl/view/31048
• Institution: Institut Teknologi Bandung

Polivinylpyrrolidone (PVP) have been used for various biomedical application as drug delivery and highly hygroscopic. Adding Cellulose Asetat (CA) can decrease drug degradation rate. Synthesis of PVP/CA fiber can mixed with many kinds of nature material extract which can use for drug delivery and wound dressing, one of them is mangosteen pericarp extract. Pericarp mangosteen extract (PME) have been used as drug for many kinds of disease, because of their antioxidant and antibacterial activity. PVP/CA fiber loaded mangosteen pericarp extract was obtained by electrospinning. Polyvinylpyrrolidone (PVP) with molecular weight of 1.300.000, CA with molecular weight of 50.000, and acetic acid 98% were used as polymer, additive and solvent, respectively. Mass ratio of PVP/CA is 6:4 with various concentration which is 8, 9, 10, 11 dan 12 wt.%. Each of PVP/CA solution was mixed with MPE solution (10 wt.%) for 6:4 mass ratio as precursor solution. Electrospinning parameters such as high voltage 12,5 kV, flow rate 1 ?L/menit and 10 cm distance between needle and collector have applied. Average diameter of electrospun fibers for each sample were 311,85 nm; 447,90 nm ; 458,53nm; 500,14 nm;and 642,48 nm. FTIR analysis showed intermolecular interactions of PVP, CA and mangosteen extract. Tensile strength depends on PVP/CA concentration. Furthermore, PVP/CA electrospun fiber loaded mangosteen extract can be developed for wound dressing application.