#TITLE_ALTERNATIVE#

• Main Author: SULISTIANA SULAIMAN NIM: 20714312, SRI
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/31064
• Institution: Institut Teknologi Bandung

Chamomile essential oil contains various kinds of chemical compounds that was <br /> <br /> useful for skin. One of them was capable to provided good protection against free <br /> <br /> radicals. The aim of this study was to develop topical antioxidant formulation in <br /> <br /> the form of microemulsion gel that had good stability and safe for skin. This study <br /> <br /> began with determined oil concentration to incorporated into microemulsion <br /> <br /> formula. Furthermore, optimization of the surfactant, cosurfactant and carrier oil <br /> <br /> concentration to produced clear microemulsion, The evaluation of microemulsion <br /> <br /> include of organoleptic, pH, viscosity, oil droplet size, oil droplet morphology, <br /> <br /> freeze thaw test and antioxidant activity test for 28 days. Then microemulsion was <br /> <br /> incorporated into gel base to form microemulsion gel. The evaluation of <br /> <br /> microemulsion gel include of organoleptic, pH, viscosity, freeze thaw test and <br /> <br /> antioxidant activity test. Irritation test as an in vivo evaluation was conducted using <br /> <br /> albino male rabbits. The results showed chamomile oil IC50 value of 101,504 ppm, <br /> <br /> 8,701 times lower than alpha tocopherol (vitamin E) IC50 value of 11,665 ppm. <br /> <br /> Optimization results of surfactant, cosurfactant and carrier oil which can produced <br /> <br /> clear microemulsion were Tween 80 30%, PEG 400 10% and Virgin Coconut Oil <br /> <br /> (VCO) 5%. Microemulsion had good stability indicated by pH range of 5 during <br /> <br /> stored at room temperature and climatic chamber with 75% Relative Humidity, <br /> <br /> viscosity range from 11 to 12 cps, stable droplets size below 50 nm, and no phase <br /> <br /> separation observed in centrifugation and freeze thaw test. Chamomile oil <br /> <br /> microemulsion IC50 value of 84.223 ppm, this antioxidant activity was 1.205 times <br /> <br /> higher than antioxidant activity of chamomile oil. Chamomile oil microemulsion <br /> <br /> gel was also had good stability indicated by pH value was remain in neutral pH <br /> <br /> range (7), viscosity from 903 to 967 cps, and no phase separation in freeze thaw <br /> <br /> test. microemulsion gel IC50 value of 80,785 ppm. Chamomile oil microemulsion <br /> <br /> gel was not irritated the skin with primary irritation index 0. <br /> <br />