#TITLE_ALTERNATIVE#

• Main Author: NGENANA BR TARIGAN NIM : 10714010, SRY
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/31069
• Institution: Institut Teknologi Bandung

Anredera cordifola or binahong is a well known to have various pharmacological activities one of <br /> <br /> which is analgesic activity. There are many compounds contained in binahong that have analgesic <br /> <br /> effects such as apigenin, rutin, vitexin, quercetin and ursolic acid, which have poor aqueous <br /> <br /> solubility. The analgesic potency of binahong extract compared to drug such as apirin is still very <br /> <br /> low so it takes a large dose to reach the comparison potency. This can be due to the low <br /> <br /> availability of the extract. Modification to increase solubility or dissolution rate are expected to <br /> <br /> increase the bioavailability of extracts. The reduction in particle size is an old conventional <br /> <br /> strategy to increase the solubility of drug for the solubility is intrinsically related to the particle <br /> <br /> size and significantly increases on reducing particle size below 1 &#956;m. This study aimed to observe <br /> <br /> the effect of particle size reduction of binahong water-ethanol extract in writhing test analgesic <br /> <br /> activity. The result showed no significant difference (&#945;<0,05) in the average writhes between <br /> <br /> extract groups and nanoparticle groups but there was an increase in percent of inhibiton on <br /> <br /> nanoparticle compared to water-ethanol extract at dose of 200 mg/kg bw in the 10th, 20th and 30th <br /> <br /> minute. In the 30th minute, the percent of inhibition of water-ethanol extract and nanoparticle <br /> <br /> extract at dose of 200 mg/kg bw were 63,37% and 65,35% respectively and the both average <br /> <br /> writhes did not differ significantly with aspirin that have 75,45% inhibition. At a dose of 100 <br /> <br /> mg/kg bw, the percent of inhibition of binahong water-ethanol extract and nanoparticle extract <br /> <br /> were 42,57% and 43,56%, respectively. At a dose of 50 mg/kg bw, the percent of inhibition of <br /> <br /> binahong water-ethanol extract and nanoparticle extract was the same i.e. 27,72%.