STUDY OF EUGENYL ACETATE SYNTHESIS OPTIMIZATION UTILIZING MICROWAVE-ASSISTED ORGANIC SYNTHESIS (MAOS) METHOD

• Main Author: DARULAN NIM:10511046, ULAN
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/31400
• Institution: Institut Teknologi Bandung

Researches on acetylation reaction of eugenol to produce eugenyl acetate have been done by many researchers. However, this topic is still interesting to be developed especially to reduce the reaction time which is still long and to minimize the use of catalysts and solvents. In this research, the acetylation eugenol reaction was done utilizing Microwave-Assisted Organic Synthesis (MAOS) method. By utilizing MAOS method, heating of the reactant will be more evenly distributed and efficient because the microwave radiation will be directly absorbed by the reactants, thereby increasing the reaction rate and decreasing the reaction time. After eugenol was mixed with acetic anhydride, the synthesis of eugenyl acetate was carried out at 150 °C for one minute using microwave irradiation at the power of 100 W. Eugenyl acetate was successfully synthesized, with 94% yielded percentage, and TLC results showed a stain difference from eugenol with a product Rf value of 0.66. The characterization of 1H NMR (500 MHz, CDCl3) of eugenyl acetate showed the presence of a single triple proton with an acetyl group (? = 2.31 ppm). Characterization by 13C NMR (125 MHz, CDCl3) showed that there were 12 signals corresponding to the amount of carbons in eugenyl acetate. The FTIR spectrum showed the loss of peak in the area of 3529 cm-1, which corresponded to the hydroxy functional group region (-OH) as a loss of eugenol, and appearance of peaks in the region of 1766 cm-1, which correspond to the carbonyl group (-C=O) and indicate the formation of eugenyl acetate.