SYNTHESIS OF OXOVANADIUM(IV)-SALEN COMPLEX AS CATALYST FOR CYSTEINE OXIDATION REACTION BY HYDROGEN PEROXIDE

• Main Author: NUR RISTAMA NIM:10513049, ZULFIKAR
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/31921
• Institution: Institut Teknologi Bandung

Diabetes Mellitus (DM) is a metabolic disorder disease caused by (i) the pancreas could not produce enough insulin, and (ii) the body could not use insulin effectively. This condition can lead to the increasing of glucose concentration in the blood. Currently, the potential of transition metal complex compounds with Schiff's base ligand as antidiabetes is widely investigated. In this study, the potential of [VO (salen)] complex as antidiabetes has been studied through in vitro studies of cysteine oxidation reactions. The salen ligand used is the result synthesis reaction of salicylaldehyde and ethylenediamine. The success of salen ligand synthesis is demonstrated by the peaks of H atom corresponding to the salen structure of the 1H-NMR spectrum. Meanwhile, the formation of the [VO(salen)] complex has been analysed using infrared spectroscopy, mass spectrometry, molar conductivity measurements, and magnetic moment measurements. The [VO(salen)] complex has a paramagnetic characteristic with an ?eff value of 1.79 BM which indicates that the complex is a neutral complex. The ability of [VO(salen)] complex as a cysteine oxidation reaction catalyst is studied by measuring E1/2 with cyclic voltammetry. The value of E1/2 complex [VO(salen)] obtained by 0.62 V, which shows tha the [VO(salen)] complex can be used as cysteine oxidizer. The qualitative test of [VO(salen)] complex as a cysteine oxidation reaction catalyst by H2O2 was done in this study and the product has been measured using 1H-NMR, but the obtained results did not show the ability [VO(salen)] complex as reaction catalyst.