COMPARATIVE STUDY OF STATIC AND DYNAMIC MULTILEAF COLLIMATOR IN INTENSITY MODULATED RADIATION THERAPY TECHNIQUE USING DOSE VOLUME HISTOGRAM ANALYSIS

• Main Author: Mutiara Firdausyi, Alya
• Format: Final Project
• Language: Indonesia
• Subjects: Fisika
• Online Access: https://digilib.itb.ac.id/gdl/view/32330
• Institution: Institut Teknologi Bandung

Radiation therapy is treatment to destroy tumors by utilizing ionizing radiation. The principle of radiotherapy is to give maximum dose to the target while give minimum dose received by the surrounding healthy tissue. This study evaluate radiotherapy treatment planning which was carried out using Intensity Modulated Radiation Therapy (IMRT) technique to 5 patients of lung cancer. This study aims is to quantitatively compare radiation therapy using static (SMLC) and dynamic (DMLC) multileaf collimator settings. Evaluation was performed using a dosimetry analysis on Dose Volume Histogram (DVH) based on data of Dose Volume Histogram. Dosimetry analysis is performed with several parameters such as Conformity Index (CI), Homogeneity Index (HI), Target Coverage Index (TCI), Conformity Number, Uniformity Index (UI), Conformal Index (COIN), Plan Quality Index (PQI) and biological parameters such as Equivalent Uniform Dose (EUD), Tumor Control Probability (TCP), and Normal Tissue Complication Probability (NTCP). The significance of the difference between the two types of MLC settings is calculated using paired t statistical tests to find out the p value as a comparison parameter. From the results of the data and processing, the use of DMLC provided better parameter values in the quality of therapeutic planning compared to SMLC. However, the results of the SMLC are still in the safe range and in accordance with the protocol so that the two MLC settings can be an option for radiation therapy.