ETHANOL EXTRACT CELERY (Apium graveolens) AS ANTI-ATHEROSCLEROSIS IN RATS (Rattus norvegicus) INDUCED HYPERLIPIDEMIA
The prevalence number of patients with coronary artery atherosclerosis triggered by increased along with the continued increase in people at risk of the disease. One of them is caused by the condition of hyperlipidemia. Hyperlipidemia is a condition in which there is a disorder of lipid metabolism t...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/36259 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | The prevalence number of patients with coronary artery atherosclerosis triggered by increased along with the continued increase in people at risk of the disease. One of them is caused by the condition of hyperlipidemia. Hyperlipidemia is a condition in which there is a disorder of lipid metabolism that involves an increase in the concentration of plasma lipoproteins. Hyperlipidemic condition causes by the increased blood lipid concentrations characterized by elevated total cholesterol, triglycerides, LDL and decrease HDL. Increasing concentrations of LDL along with oxidative stress as a key trigger of the atherosclerosis. This study aimed to evaluate the administration of a preparation the ethanol extract of celery (Apium graveolens) to rats (Rattus norvegicus) Wistar strain induced hyperlipidemia. A total of 25 male rats divided into five, namely: group I as a negative control only fed by pellets and distilled water through gavage, group II as a group hyperlipidemia induced hyperlipidemia (high feed fat + cholesterol crystals + PTU), group III as the positive control group induced hyperlipidemia (high fat feed + cholesterol crystals + PTU) and were given the simvastatin at a dose of 0.9 mg / kg. Group IV and V was induced hyperlipidemia (high fat feed + cholesterol crystals + PTU), and given the celery extract with each dose of 125 mg/ kg rat and 250 mg/ kg rat. Treatment was administered orally gavage for 4 weeks for the induction of hyperlipidemia and 4 weeks for the administration of simvastatin and celery extract. Panel blood lipids were measured enzymatically, atherogenic index measurement (IA) is performed by using the equation: IA = (total- cholesterol HDL cholesterol) / HDL cholesterol by Matsubara et al. (2002) and oxidative stress was measured by TBA method for measuring the concentration of MDA. The results were tested by ANOVA followed by Tukey's test and gamess-Howell at the 0.05 level. The results of analysis was showed that the ethanol extract of celery dose of 125 mg/ kg BW and a dose of 250 mg/ kg BW effectively lowers total cholesterol and effectively increase HDL levels and therefore reduces IA test animals induced, it is also the ethanol extract of celery a dose of 250 mg/ kg BW effectively lowers plasma levels of MDA and MDA aorta. Based on the results obtained can be concluded that the extract of celery can lower the risk of atherosclerosis in hyperlipidemic mice by improving blood lipid profiles and decreases oxidative stress status. |
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