EVALUATION OF HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PARKINSON’S DISEASE: A LEVDOPA- BASED THERAPY APPROACH

• Main Author: Oktariza, Yasinda
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/37142
• Institution: Institut Teknologi Bandung

Health-related quality of life (HRQoL) assessment has been widely used as a secondary parameter for therapy evaluation in patient with chronic, progressive, and degenerative disorders like Parkinson’s disease (PD). Patients with PD are particularly vulnerable to deterioration of quality of life due to significant motor disability and the burden of non-motor symptoms. Long term therapy also gives contribution in worsening quality of life as an adverse event rises over time. Therefore, this study aimed to explore the effect of therapy on HRQoL and identified factors that influence the HRQoL in patients with Parkinson’s disease. Thirty-three subjects with minimum one year of treatment containing levodopa were assessed using an Indonesian-translated version of the 39-item Parkinson’s disease questionnaire (PDQ-39). Mean score of PDQ-39 between treatments in a cross-sectional design were calculated and the subgroup analyses (by baseline characteristics and occurrence of adverse events) were conducted using the same approach. Bivariate analysis revealed there is no significant changes in mean score of PDQ-39 between treatment with levodopa combination (p=0.262). Based on the result of multivariate analysis, factors that independently correlated to patient’s quality of life in Parkinson’s disease in this study were exercise (r=0.233), severity (r=0.464), and motor complications (r=0.329). Results suggest that total quality of life in patients with Parkinson’s disease were not significantly affected by variation of treatment but correlated to levodopa-related motor complications during therapy.