PREPARATION AND CHARACTERISTIC LIQUISOLID RAMIPRIL TABLET

• Main Author: Faisal Budiman, Muhammad
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/37363
• Institution: Institut Teknologi Bandung

Ramipril is an angiotensin-converting enzyme inhibitor which has low solubility and high permeability. Ramipril is belong to class II drug in Biopharmaceutical Classification System. The low solubility of ramipril leads to low dissolution and therefore this study is aiming to increase solubility and dissolution of the this drug by using liquisolid techniques. Liquisolid tablets were prepared by using propilen glikol and transcutol as vehicle, Avicel PH 101 (Q) as carrier material and Aerosil (q) as coating material. Liquisolid preparations were constructed by using Q and q at ratio 20:1. Drug concentration in liquid vehicle were 15%, 20%, 25% and 30%. The characterization of raw material and liquidsolid mass were done by using Fourier Transform Infrared (FTIR), Scanning Electron Microscope (SEM), Differential Scanning Calorimetry (DSC), and X-Ray Diffraction (XRD). The tablets formulation were evaluated include description, friability, disintegration time, assay and dissolution. In vitro dissolution studies were performed at three pH conditions 1.2, 4.5 and 6.8. The result showed that the characteristic of raw material used was in accordance with ramipril in the literature. Charaterization of liquidsolid mass with FTIR and XRD showed that all liquisolid formulation spectrums and difractograms were look like an Avicel spectrum and difractogram. Liquisolid with propilen glikol as vehicle had expressed faster dissolution profile than transcutol formulation. Formula FL03 and FL 04 dissolution profiles were similar with innovator (Triatec). FL04 had the best dissolution efficiency (DE) value among the studied formula and approaches innovator dissolution efficiency value of 88.30%±4.01 at pH 1.2, 89.32%±2.04 at pH 4.5 and 93.58%±3.90 at pH 6.8.