Isolatio n of Curcumin from C. xanthorrihza and Synthesis of Mn-curcumin Co mplexes

• Main Author: Pasman, Holly
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/37863
• Institution: Institut Teknologi Bandung

In this research, curcumin {1,7-bis(4-hydroxy-3-me thoxyphe nyl) -hepta-1,6-die nne-3,5- dione }, was isolated from rhizomes C. xanthorrhiza (Zingiberacea family) , which is traditionally known as “temulawak”, us ing a gradua l isolation methods (extraction, fractination, and pur if ication). The pure curcumin obta ined, then, mixed w ith sa lts of some essentia l metal ions in solution to synthesize M-Curcumin complexes (M = metal ion), in which manganese, Mn2+, from it’s nitrate and sulfate salts (Mn(NO3)2 and MnSO4) was particularly investigated. The complexes were synthesized us ing two synthetic routes, that is, by stirr ing or mixing at or dinary temperature, and by ref lux at 85ºC for 4 hours. The characterization of the compounds and eluc idation of the ir structure were conducted using MS, IR, and UV-vis spectroscopy. Some sharp peaks of IR spectra from the pure curcumin which appear at 1874,6 and 1626,4 cm-1 were not seen in the Mn-Curcumin complexes spectra. These signif icant results indicate the strong interaction of Mn2+ and the curcumin in the Mn-Curcumin complexes which perhaps form certain degree of covalent bonds. And, two peaks of UV-vis spectra from Mn-curcumin complex which can be seen at 420 and 442 nm also indicate the formation of a strong bond between the metal ion and the curcumin as “ligand” in the Mn-Curcumin complexes. Moreover, MS spectra from the three complexes of Mn-Curcumin: 948,75, 1158,43, and 790,22 m/z, confir med that manganese ion, Mn2+, and curcumin formed complexes with the stoichiometry 1:2 and 1:3.