Piron Derivatives from Leaves of Indonesian Cryptocarya nitens

• Main Author: Erlinda Octarina, Risa
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/38076
• Institution: Institut Teknologi Bandung

Cryptocarya is a genus of Lauraceae family which grows in Asia, Australia dan Melanesia. In Indonesia, it is locally known as “huru” or “medang”. This genus has been used as building materials, pulp in paper industries, and traditional medicines. The use of this genus made it is interesting to be studied for its phytochemistry. The literature study showed that Cryptocarya contains secondary metabolites i.e. pyrones, flavonoids, alkaloids, stilbenes, lignans, terpenoids, steroids and carboxylic acids. Alkaloid is the main secondary metabolism of Australian Cryptocarya while pyrones and flavonoids are two major secondary metabolites of Indonesian Cryptocarya. One of Indonesian Cryptocarya is Cryptocarya nitens. The isolated compounds of this species was yangambin (132) from the stem, while (-)-(6S,2’R)-deacetylcryptocaryalactone (165) and cryptofolione (22) were obtained from the leaves. However, the research on leaves of Cryptocarya nitens has not yet finished, therefore the continuation of research has to be continued. The fractionation and purification process were conducted by using various chromatography techniques, such as vacuum liquid chromatography, gravity column chromatography and radial chromatography. In this research, eight isolates have been isolated successfully from methanol extract of Cryptocarya nitens leaves. Five of them were suggested to have structure of cryptocaryalactone (163 and 164) and one isolate was identified as (+)-(6R,2’R)- deacetylcryptocaryalactone (166). Both are pyrone derivatives. Beside that, the structures of other isolates are still being analyzed. Based on NMR analysis, optical rotation, thin layer chromatography and compared the literature data, five isolates were have been suggested as cryptocaryalactone (163 dan 164) are diastereomer. Three isolates were suggested to have structure of (+)-(6R,2’S)-cryptocaryalactone (163) and two isolates were suggested to have structure of (+)-(6R,2’R)-cryptocaryalactone (164). Cryptocaryalactone (163 and 164) and deacetylcryptocaryalactone (166) were reported for the first time from Indonesian Cryptocarya plant. However, both compounds have also been isolated from other Cryptocarya species, i.e. C. bourdillonia, C. liebertiana, C. moschata, and C. wyliei.