VOLTAMMETRY AND POTENTIOMETRY STUDIES OF BUTYLATED HYDROXYTOLUENE (BHT) USING CARBON PASTA ELECTRODA (CPEs) MODIFIED BY MOLECULARLY IMPRINTED POLY (GLUTAMIC ACID)

• Main Author: Ma'ruf, Ahmad
• Format: Theses
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/38517
• Institution: Institut Teknologi Bandung

Voltammetry and potentiometry studies using carbon paste electrodes (CPEs) modified by molecularly imprinted poly (MJP) are needed for the measurement of certain compounds with high selectivity and sensitivity. In this study, the compound that wanted to be analyzed was butylated hydroxyto/uene (BHT) which is an antioxidant compound synthesizing phenol derivatives. The use of BHT as an important antioxidant in the pharmaceutical industry because it can prevent the rate of oxidative reactions from organic compounds in the product. However, the use of BHT can harm health because it is carcinogenic, therefore its use in pharmaceutical products has a permissible amount of0.0075- 0.1%. The method that has been used in BHT analysis is GC-MS and HPLC. Not many have analyzed BHT by voltammetry and potentiometry. Su that it takes measurements with other methods as a comparison. Voltammetry is an electrochemical technique that is developing and is a concern. The use of MIP has many advantages, which have high stability and can be used for various molecules in the fields of chemistry, biology, and pharmacy. EPK-MIP is prepared by electropolymerization using glutamic acid as a monomer and BHT as an analyte using cyclic vo/tammetry technique. Then the EPK-MIP was used as the working electrode on the potentiometer to analyze BHT in the sample and Ag!AgCl was used as the reference electrode. The effect of variations in analyte composition : monomers, electropolymerization cycles, and pH of the solution were studied to obtain the optimum measurement conditions. The results showed that BHT analysis using potentiometry using carbon paste electrodes modified by MIP had a wide range of measurements of 1o-7 - J0-3 M with a detection limit of 6.1 x J0-6 M The precision test showed the %RSD value pretty good which is below 2%. Determination of BHT by potentiometry, voltammetry and compared to HPLC in Kanna cream samples showed the concentration values contained therein of 0.65 mM, 0.60 mM, and 0.66 mM or if it is specified that is 1.32 x 10- 5%. After the results of the three concentrations were analyzed by ANOVA, the Fexpemnent > Fcrilicatvalue was 30.2 > 9.5 which showed that there was no significant difference in the measurement of BHT concentration using the three methods