Potential Study of Oxovanadium(IV)-Imine and Oksovanadium(IV)-Diketone as Antidiabetic

• Main Author: Kusumawardani, Maulinda
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/38584
• Institution: Institut Teknologi Bandung

Diabetes is one of the most deadly di!>ea!>eS and there has been no effective treatment until now. At present. one of the emerging research is designing inorganic compounds that have the potential to be antidiabetic. Inorganic compounds that are designed are expected to have a working mechanism that i!> targeted at u-amy lase to cure diabetes. One of the antidiabetic inorganic compounds v.-hich has been studied for potential is the Okso\anadium ( IV) comple\. \vith diketone dcri\ative ligands. In this stud) . the comple:-. compound studied \\aS Oksovanadium (IV) -diben7oi lmethane (VO-DBM). The compounds dibenzoilmethane have been succes!>fully S)nthesi?ed and have been characterized by FTIR and NMR spectra. The green Oxoma\anium (IV) -DBM compound has been successfully synthesized. The IR spectrum of VO- DBM compounds shov.s peaks similar to the infrared ligand spectrum. The presence of ad-d transition and charge transfer are seen in the UV-Visible spectru m. The moment value of the Oksovanadium ( IV ) magnet -DBM is 1.81 BM indicating that each I igand has formed an Okso\anadium (IV) comple:-. compound \\ i th octa hedra l geometl) d I. Confirmed the complc:-. structure of VO-DBM from CI-IN analysis. VO-DBM has an IC51l of 0.41 111\1 against a-amylase acti\ity \\hich indicates that this complex has promising antidiabetic potential.