TRJTERPENOIDS FROM SANDOR/CUM KOETJAPE LEAVES AND ITS ANTIBACTERIAL ACTIVITIES

• Main Author: Saptanti, Karlina
• Format: Theses
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/38765
• Institution: Institut Teknologi Bandung

,\'wuloncum koet;ape (Ateltaceae} or "Kecap1", tradlltonal r often used as medtcme and phytochemtcal exploratiOn al the S. koeuape lem•es has n01 hc>en wtdely U\ed. Therefore. tht'i research purpo•,ed to t'iolate and de!emune !he slruc!ure of \econdary metahollle\ from of S. koeuupe leave'• and detemme the anubactenu/ acl/vtty of pure compound\. 1\o/arwn of secondar_v metaholaesfrom S. koeljupe leave\ wa\ earned our rhrough se rera/ stages: extracTion, fracuonutton. and pzmficauon u.\mg mnou.\ clmmwtographu.: methods: lujwd vacuum chromaiOf!ruphy. grm•lfy chromatography. and radtal chromatography. The struclure determmauon of pure compound\• was earned out based on I f) and 2D NAIR 'ipeura and opuca! rotatton. lnrhe.fina/ stage r?lThe research, the leave.\ extracT' and pure compound\ .from the twlation were lested for antihaclenal actll't ty agam\l two (jram ( } bactena (h'nrerococcus faecalts and Staphylococcu' 'aprophyllCU\} and Mo Gram - (-} bacteria (Citrobacterfreundil and ,'a/monel/a enterica). Ba\.ed on tho.\e merhodolog_v. stx pure compoundhave been ir;o/ated from ,)'. koeuape leave•,: bnonomc acf(/ (penta<-:rc!rc tnterpenotd} (I). hnonoltc aCid (pemacycltc trtterpenmd) (2). katonomc actd (penta<-ycltc tnterpenmd} (3}. compound H-.23-1 (pentac vc flc pentotnterpemoid) (-1). HIJC./2-1-1 (pemacychc tnterpenoid} (5}, and HIJ 10.(pentacyc/;c lrtletpenoid) (6). Based on the 'ilx compound.\, three of them, compound<; (-I), (5). and (6) are new compound<> m nature. The remit l( antibacterial assay on leaf extract and pure compowul.\ wtth amoxlctllm and chloramphemcol \landard\ showed mactn•tty w anllhuctenal.,. In condu.\LOn, m this re\•earch SIX pure compound\ .from !he tnterpeno{( / group were t.wlated w11h three new lriterpemnd compound\•.