L-PROLIN SEBAGAI NATURAL DEEP EUTECTIC SOLVENTS (NADES) UNTUK PENINGKATAN KELARUTAN DAN DIFUSI TRETINOIN

• Main Author: Maraya Ulfah, Tasya
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/40369
• Institution: Institut Teknologi Bandung

Nowadays, the restriction and reduction of not environmentally friendly substances become one of the main considerations on raw materials development. Because of the low solubility of some drugs, the usage of organic solvent still often used to increase solubility. Hence, the safer compound is explored intensively to replace the conventional solubility enhancer. One of this is the use of Natural Deep Eutectic Solvents (NADES). L-proline (PRO) is an amino acid that has been reported can enhance the solubility and absorptivity of other compounds. This research attempted to combine PRO with the insoluble vitamins, namely tretinoin (TRET). The binary system between TRET-PRO was characterized by solid analysis instrumentation, such as thermal analysis using electrothermal and DSC as well as non-thermal analysis using FTIR and PXRD. The eutectic mixture was collected through grinding which was aided by solvent dropping. This method is called solvent drop grinding (SDG). In addition, it was also done the recrystallization using ethanol. Furthermore, it was observed the solubility, diffusion, and stability of TRET after eutectic interaction with PRO. The thermal data revealed that this natural eutectic former decreased the melting point of TRET from 182°C to 147.6°C at rasio molar 1:1. The results of non-termal analysis showed that no shift or new peak formation in the FTIR spectrum and PXRD diffractogram. The data reinforces the conclusion that the mixture is an eutectic system without producing a new phase. The results of solubility test show that PRO can increase solubility of TRET in water by 3.335 times. This mixture can also increase diffusion of TRET in pH 7.4 by 3.735 times. In addition, through the stability test it was proven that the eutectic mixture can increase stability of TRET against light and oxidation, but absorb water faster than the environment compared to the single material. In conclusion, PRO functions as a NADES agent for TRET which can increase solubility, diffusion, and stability of TRET.