INTERMOLECULAR INTERACTION STUDIES OF METFORMIN HCl AND GLIMEPIRIDE MIXTURES AND EFFECT OF THE INTERACTION ON SOLUBILITY AND DISSOLUTION OF GLIMEPIRIDE
Intermolecular interaction between two active compounds could effect of physicochemical properties of the compounds. Identification of intermolecular interaction between glimepiride (GMP) and metformin HCl (MET) by fusion method, solid state grinding (SSG), solvent drop grinding (SDG) and solvent...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/40420 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Intermolecular interaction between two active compounds could effect of
physicochemical properties of the compounds. Identification of intermolecular
interaction between glimepiride (GMP) and metformin HCl (MET) by fusion
method, solid state grinding (SSG), solvent drop grinding (SDG) and solvent
evaporation (SE) with ratio molar 1:1 had been carried out. The result of fusion
method in methanol as a solvent shown new crystal habit of GMP-MET physical
mixture as small tabular shaped which indicated an intermolecular interaction
occured. Identification of GMP-MET mixture based on DTA/TG thermogram
shown two new endotermic peaks corresponding to peritecticum at temperature
197,02 and 216,64
o
C. Microscopic analysis by SEM of SE method showed the
change of habit and morphology crystal to be a long tabular shaped. There are no
new peaks found in PXRD and FTIR data. The solubility and dissolution of GMP
after treatment increased by SSG, SDG and SE methods even from physical mixture
in phosphate buffer medium pH 7.4. The highest solubility and dissolution values
obtained from SDG method 0,041 mg/ml and 57,33% respectively.
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