DRUG INTERACTION IN URINARY TRACT INFECTION IN THE INWARD PATIENT OF Dr. HASAN SADIKIN BANDUNG HOSPITAL ON AUGUST 2017 - JULY 2018 PERIOD AND ITS ASSOCIATION TO THERAPEUTIC OUTCOME

• Main Author: Anggraini, Julia
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/40446
• Institution: Institut Teknologi Bandung

Urinary Tract Infection (UTI) is one of the dominant infection diseases. Urinary Tract Infection is the highest hospital-acquired infecion (HAI) in Indonesia. Some antibiotics used for urinary tract infection have an important role in drug interaction, which may result in the harmful outcome for the patient. In Indonesia, research about drug interaction in UTI patient is still focusing on descriptive research only. This study aim to analyze the association between drug interaction and the UTI patient’s therapeutic outcome (clinical recovery and length of signs/symptoms recovery) in Dr. Hasan Sadikin Bandung Hospital on August 2017 –July 2018. Retrospective, cross-sectional sudy has been done. 155 patient who met criteria inclusion and exclusion in this study, were classified in 2 groups, determine as group without drug interaction and group with drug interaction. There was 509 (41,6%) potential drug interaction in 1224 prescription for UTI patient. The incidence of drug interaction was 5.2 DI/patient. Most of drug interactions were interaction between drug and drug, with both pharmacodynamics dan pharmacokinetics mechanism, the severiy were moderate and severe. The effect of drug interaction is potentially harmful to the UTI patient. We found that 4,71% of drug interaction represent iatrogenic effects on 14 patients. The differences of clinical recovery between two groups was 12%, but this is not significant statistically (p>0,05). But this number shows that drug interaction in UTI patient can decrease patient’s clinical recovery about 12%. And the differences between length of signs and symptoms recovery between groups was 4 days (p<0,001). This means drug interaction can prolonged the time of UTI signs/symptoms recovery for 4 days.