EFFECT OF CELLULOSE ADDITION TO COMPRESSION STRENGTH AND SWELLING RATIO ON ALGINATECHITOSAN- CARBONATE APATITE BASED BONE SCAFFOLD

• Main Author: Aditama, Pratama
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/42453
• Institution: Institut Teknologi Bandung

Bone damage is one of a case of organ damage with a high number of events. One of the concerns is complicated bone damage, loss of bone parts, and difficult regeneration processes. Currently, bone repair methods have been developed by growing bone cells using a three-dimensional structure as a guide while the bone cells grow on the damaged bone. The three-dimensional structure is called bone scaffold. Until now, research is still being conducted to find bone scaffold material that has important properties in tissue engineering. This study aimed to determine the effect of cellulose on the compressive strength and swelling behavior of alginate, chitosan and carbonate apatite-based bone scaffold. Bone scaffold was made by freeze drying method to get interconnected porosity. Bone scaffold was made into 3 samples with different variations in cellulose concentration. Sample A was not added cellulose, sample B was added 1% w/v cellulose, and sample C was added 2% w/v cellulose. Analysis of the results of scanning electron microscopy showed that with the addition of cellulose there was an increase in bone scaffold's pore size. The compressive strengths of each of the bone scaffold samples A, B, and C were 23.3 kPa, 99.1 kPa, and 107.3 kPa respectively. Swelling ratios of each of the bone scaffold samples A, B, and C were 1613%, 2940%, and 2721%, respectively. This proves that cellulose can increase the ability of swelling and compressive strength in alginate, chitosan, and carbonate apatite-based bone scaffold.