SYNTHESIS, CHARACTERIZATION AND STUDY OF ANTI­ DIABETIC POTENTIAL OF OXOVA NADIUM(IV) COMPLEXES WITH 2,2':6',2"-TERPYRIDINE AND 2,6-DI(PIRAZOL) PYRIDINE LIGA NDS

• Main Author: Nisa, Fakhrotun
• Format: Theses
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/42549
• Institution: Institut Teknologi Bandung

The number Slffferers of diabetes mellitus is increasing every year so the study about anti-diabetes material continue to develop. Oxovanadium (IV) complexes have anti-diabetic potential because it can act as insulzn mimetic and have been tested in vivo and in vitro. Oxovanadium (1V) complexes have been synthesi:::ed with various hgands that vary the coordination number and types of atomic donors. Ussually, the ligands have been used is• the bidentate ligand with oxygen donor and recently started in ligandr; with nitrogen donor. in addition, oxovanadium(JV) with tridentate ligands have not yet popular as anti-diabetic. For example the oxovanadium (IV) complex with terpyridine ligand, but this research is only limited to computational structure and studies. Therefore, in this study the complex was synthesi:::ed within the study of anti-diabetic potential. This complex is synthesi:::ed from the reaction of voso4 in water with pyridine in ethanol at room temperature. Green solids as 0.2 g were produced with an 22% yield This complex has the 1 molecular formula C1sHuN30sV 12 H20 ({VO(terpy)]S04. 2HzO) which proving by elemental .anal vsis and TGA data. This complex is paramagnetic with a magnetic moment valuef 1.68 BA1. The coordination between vanadyl and ligand is showed by the shifting peak of the C-N bond vibrations from the ligand spectra to the complex to smaller wave numbers. This complex soluble in water and produces a 2:2 charge with a molar conductivity value of 236 S cm2 mol -1 which is compared with a VOS04 molar conductivity value. In addition. the [VO(terpy)ji+ ion mass was showed in the mass spectrum at 150m:::. The [VO(terpy)}S04. 12 H2 0 complex was stable until the seventh day and had anti-diabetic potential by lowering the blood sugar levels of rats to the normal limit on the third day at a dose of 0,03 mg V kg body weight. This complex can also inhibit the human saliva a­ amylase (H/:)) en:::yme by 2-1% compared to JC 50 acarbose as standard As a complement, oxovanadium (IV) complex with tridentate ligand in pyridine (pyra:::ole) or 3-bpp also synthesi:::ed where two pyridine rings on terpyridine are replaced with pyra:::ofe. The 3-bpp ligand is synthesi:::ed through two reaction steps, firstly the reaction between diacetyfpyridine and dimethy(formamide dimethylacetal which produces intermediate products. then the second step is with hydra::ine hydrate for the cycli::ation process toform a pyra::ole ring. This ligand has a melting point of 253-255 tt•. The results of characteri:::ation by FT.!R slww the peaks with the same wave numbers us the literature. After the ligand isformed, the synthesis ofthis complex is carried out by refluxing the voso4 solutiOn 111 water and •3-bpp ligand solution in ethanol with the result of a blue solid of0,36 g with 37% yields. Thzs produces a complex with the molecular formula CnH9N5Q5SV3H20 or [V0(3-bpp)]S04.3H20 which is paramagnetic because it has a magnetic moment value of 1.71 BM. in the infrared spectrum there is a weakening of the secondary amine bond, which mdicates the coordination of the ligand w1th the vanadyl ion. This complex shows a molar conductivity of228 S em:! mol-1 and there is a peak at 139 m :: which supports that this complex is cationic. Anti-diabetic potential comple.x {V0(3-bpp)]S0 4.3H20 can reduce blood sugar levels to normal on the fifth day at a dose ofO, 125 mg V kg body weight and inhibit HSA en::ymes higher than [VO(terpy) JS0 4. 12H20, which is 32%. Thus, the [VO(terpy) JS04. 1:H20 and {V0(3-bpp)J S04.3H20 complexes have anti-diabetic potential.