IDENTIFIKASI REAKSI OBAT MERUGIKAN PADA KULIT DAN PENANGANANNYA DI RSUP DR. HASAN SADIKIN BANDUNG

• Main Author: Pramasynta, Auliyanisa
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/43684
• Institution: Institut Teknologi Bandung

Cutaneous Adverse Drug Reactions (CADR) are reactions to the skin or mucocutaneous areas that occur due to drug administration that used as prophylaxis, diagnosis, and therapeutics dosage. In the WHO global ADR database, 18,3% of over 13 million ADR reports received from more than 100 countries is CADR, so skin is the third most frequently reported system organ. WHO also mentions, about 2% of all types of CADR that arise are classified as serious even cause death, with the most common cause is antibiotics. This study aims to identify the incidence and most diagnosis types of CADR, drug suspects and dosage forms that most cause it, also analyze the drug therapies to heal it in RSUP Dr. Hasan Sadikin Bandung. This research is a descriptive study with retrospective methods through monitoring reports of adverse drug reactions (BPOM yellow form) and medical records in January-December 2018. The number of samples was 67 based on total sampling during the April-June 2019 study period. The results showed the incidence of CADR in outpatient is 23 and 44 inpatients. Most diagnoses were drug eruption both in outpatient (86.96%) and inpatient (38.64%), followed by Steven Johnson Syndrome (SJS) (25.00%) in inpatient and (13.04%) in outpatient. The most suspected drug group as the cause is antibiotics, both in inpatient (59.10%) and outpatient (47.48%). The most suspected drug is paracetamol (31 people). Tablets being the most dosage form causing cutaneous adverse drug reactions. The most widely used therapies are a combination of topical corticosteroids, systemic corticosteroids, and receptors H1 antihistamines. Therapy results showed 61% of inpatients and 43% of outpatients experienced improvement and 25% of inpatients recovered with the therapy given. Keywords: Cutaneous adverse drug reactions, drug eruption, Stevens Johnson Syndrome, corticosteroids, antihistamines