PENINGKATAN LAJU DISOLUSI ALBENDAZOL DENGAN METODE SPRAY DRYING

• Main Author: Maretha, Yossy
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/43928
• Institution: Institut Teknologi Bandung

Albendazole is a broad-spectrum anthelmintic. This drug is a part of benzimidazole carbamate widely used to treat infections caused by cysticsercosis, echinococcosis, nematode including ascariasis, enterobiasis, hookworm, stronglyoidiasis and trichuriasis (Sweetman. 2009). According to the Biopharmaceutical Classification System (BCS), this drug is in Class II where the solubility is low and has an adequate permeability (Torrado. 1997). To overcome these limitations, there are many strategies can be used such as salt formation, cosolvent, complexation, and combination with carriers. This study aimed to make microcapsules that can be used to enhance dissolution rate of albendazole using 2 different hydrophilic polymers and compare them. Microcapsules made with spray drying methode were prepared with the ratio between drug and polymer 1:1, 1:2, 1:4 (w/w). Viscosity of polymers (0.5 , 1, 2% w/v) was adjusted first before making feed solutions. Feed solutions were prepared by using albendazole, PVP K-30, lactose, and aerosil in respective ratio. Another formula for feed solutions were prepared by using albendazole, PEG 6000, lactose and aerosil in respective ratio. Evaluation of microcapsules was carried out on the percentage yield, encapsulation efficiency, particle size, morphology of particle, and in vitro dissolution. pH of feed solutions was in range 4.16 to 6.31. Highest percentage yield was 42.67% and highest encapsulation efficiency was 71.50 ±5.13% for PEG F-3. Scanning electron microscope showed the distribution of the size of albendazol with carrier PVP K-30 was 2-10 ?? and the size albendazol with carrier PEG 6000 was 3-10 ?? . Diffraction pattern showed that both microcapsules with different carriers were amorphous. Dissolution results showed a drastically enhanced dissolution rate in PVP F-1, with the highest percentage was at 81.66±1.44% in 60 minutes. Enhanced dissolution rate varied in every formula. Similarity factor showed there was a similiraty between PVP F-1 with PEG F-1, PVP F-2 with PVP F-3 and PEG F-2, and PVP F-3 with PEG F-3. According to the results, dissolution efficiency of PVP F-1 was 74.64± 3.21% and PEG F-1 was 69,61±6,63% in 60 minutes. Both results showed that they were not significantly different with each other (p> 0,05).