POLA SENSITIVITAS BAKTERI TERHADAP ANTIBIOTIK DI UNIT PERAWATAN INTENSIF DAN HIGH CARE UNIT DEWASA RUMAH SAKIT AL ISLAM BANDUNG

• Main Author: Rima Leni Ramadani, Neng
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44036
• Institution: Institut Teknologi Bandung

Irrational use of antibiotics can cause bacterial resistance. Documentation of antibiotic sensitivity patterns can be used as an additional information for rational antibiotic selection so that it can improve patient safety. This study aims to determine the antibiotic sensitivity pattern and examine the shift in bacterial sensitivity to antibiotics in the Intensive Care Unit (ICU) and Adult High Care Unit (HCUD) at Al Islam Bandung Hospital so that effective antibiotics can be determined. This study was an observational study using retrospective data in the form of antibiogram data from the bacterial sensitivity tests for ICU and HCUD patients in ten test periods (each period equal to six months) from January 2014-December 2018. The antibiotic resistance threshold was ?40%. The significance of a shift in bacterial sensitivity to antibiotics was measured using a statistical analysis by Chi-square test with 0.05 significance level. The most infected type of specimen was sputum as much as 75% of the total specimens from ICU as well as 60% of the total specimens from HCUD. The bacteria that infect most patients in the ICU was A. baumannii by 25% and in HCUD was S. epidermidis as much as 23.16% of the total bacteria that infect each room. The result of antibiotic sensitivity pattern showed that A. baumannii which infects patients in ICU was only sensitive to cotrimoxazole with a percent sensitivity of 50.67% and S. epidermidis that infects HCUD patients was sensitive to several alternative antibiotics such as netilmycin, tazobactam, doxycycline, tetracycline, and linezolid with the best percent sensitivity was netilmycin at 77.27%. There was a shift in sensitivity that was statistically significant in ICU for following bacteria: S. epidermidis against gentamicin, A. baumannii against ampicillin-sulbactam, while in HCUD were S. epidermidis against cotrimoxazole, and E. coli against doripenem as indicated by the value of Chi-square count > Chi-square table and P value < 0.05.