CHARACTERISTICS AND TREATMENT SUCCESS OF PULMONAL TUBERCULOSIS WITH DIABETES MELLITUS PATIENTS USING FIRST-LINE ANTITUBERCULOSIS DRUGS AT ROTINSULU LUNG HOSPITAL BANDUNG

• Main Author: Nurhidayah, Isnaefi
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44057
• Institution: Institut Teknologi Bandung

Background and objectives: Treatment success of tuberculosis (TB) with diabetes mellitus (DM) patients are decreased compared with tuberculosis patients without diabetes mellitus according previous studies. Few of the reasons are difficulty of controling hiperglycemia condition, cardiovaskular events, and increased risk of adverse effects from drugs/deseases during TB treatment. The objectives of the study are to know the proportion of treatment success of pulmonal TB using first-line TB drugs with DM in Rotinsulu Lung Hospital, and the assosiations with the patients’ sociodemography, clinical, and treatment characteristics. Methods: cross-sectional analytical design. Conducted retrospectively from secondary data of pulmonal tuberculosis with diabetes mellitus patients using firstline antituberculosis drugs in Rotinsulu Lung Hospital during 2015-2018 to know the characteristics of pulmonal TB with DM patients on first-line TB drugs treatment, and the treatment success. Results: From 4520 patients of pulmonal TB at Rotinsulu Lung Hospital, 239 patients (5,3%) are new pulmonal TB patients with DM. Of 182 new pulmonal TB with DM patients using first-line antituberculosis drugs, 76 patients become subjects in this study. Treatment success proportion of pulmonal TB with DM patients using first-line TB drugs in Rotinsulu Lung Hospital are 73,5%, with the most frequent duration therapy is 7-9 months. Multivariat analysis result shows prescription of antihipertensive drugs has AOR (Adjusted Odds Ratio) 0,14; 95%CI 0,02-1,16 and hospitalisation during TB treatment has AOR 2,5; 95%CI 0,76 – 8,25. Conclusions: treatment success proportion of pulmonal TB with DM patients using first-line TB drugs in Rotinsulu Lung Hospital has similar result with previous study in Indonesia in 2007. There are associations between prescription of antihipertensive drugs and hospitalisation during TB treatment with treatment success of pulmonal tuberculosis.