PENINGKATAN LAJU DISOLUSI IBUPROFEN DENGAN SISTEM DISPERSI PADAT

• Main Author: Khairunnisa Fajari, Azkia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44225
• Institution: Institut Teknologi Bandung

Ibuprofen is a non-steroidal antiinflamation drug (NSAID) which classified as class II in Biopharmaceutical Classification System (poor solubility in water and high permeability drug). This study aims to improve the dissolution rate of ibuprofen by solid dispersion technique with PEG 6000 dan Poloxamer 188 as carriers. Solid dispersions were made by solvent evaporation method. Solid dispersion with PEG 6000 as carrier were made in the ratio of 1:0,5, 1:1, and 1:1,5, with poloxamer 188 were made in the ratio of 1:0,5, and with the combination of PEG 6000 and Poloxamer 188 were made in the ratio of 1:1:0,1, 1:1:0,25, and 1:1:0,5. Physical mixtures were made in the same ratio as solid dispersions to compare the dissolution characteristics. Dissolution tests were performed on pure ibuprofen, recrystallized ibuprofen, solid dispersions and physical mixtures. The amount of ibuprofen were analyzed by Spectrophotometer UV-Vis at 221 nm. Dissolution efficiency and similarity factor of each formula were calculated and compared. Solid dispersion of ibuprofen containing PEG 6000-Poloxamer 188 as carriers at the ratio of 1:1:0,25 showed higher dissolution efficiency drug release in 60 minutes: 67,53 ± 0,88%, which gave twice fold increase in dissolution efficiency compared with pure ibuprofen. FTIR analysis showed no additional and shift in peak of IR spectrum of solid dispersion and physical mixture of ibuprofen. XRD analysis showed the decrease of cristallinity rate of Ibuprofen in solid dispersions. SEM analysis showed that the particles of solid dispersion were different from pure ibuprofen.