PENGARUH KININ, METABOLIT KININ DAN KLOROKUIN TERHADAP HEMOLISIS DARAH PENDERITA MALARIA DAN DARAH MANUSIA SEHAT SECARA IN VITRO
</i><b>Abstract: </b><p align="justify"><i> The influence of quinine, quinine metabolites and chlo roquin at concentrations of 10<sup>-9</sup>M-10<sup>-2</sup>M at 0%-0.9% NaCl tonicity on hemolysis of blood from malaria patients and he...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/4425 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | </i><b>Abstract: </b><p align="justify"><i> The influence of quinine, quinine metabolites and chlo roquin at concentrations of 10<sup>-9</sup>M-10<sup>-2</sup>M at 0%-0.9% NaCl tonicity on hemolysis of blood from malaria patients and healthy people had been investigated <u>in vitro</u>.<p align="justify"> The degree of hemolysis of blood from healthy people and apparently also from malaria patients did not differ significantly (P<0.05) at a concentration of 10<sup>-9</sup> M, at blood level concentration (5.10<sup>-5</sup>M for quinine and 3.10<sup>-7</sup>M for chloroquin) and at concentration of 10<sup>-3</sup>M at all tonicities studied, but the degree of hemolysis was significantly greater for chloroquin relative to quinine at a concentration of 10<sup>-6</sup>M and tonicity of 0.25%, 0.55%, and 0.90% NaCl (P<0.05).<p align="justify"> The degree of hemolysis was very different for the two compounds at a concentration of 10<sup>-2</sup>M and tonicities of 0.25%-0.90% NaCl (P<0.01); quinine increased while chloroquin decreased hemolysis. The same profile was seen with blood from malaria patients.<p align="justify"> The degree of hemolysis of blood from healthypeoplecaused by quinine and quinine metabolites at a concentration of 10<sup>-9</sup>M, at blood level (5.10<sup>-5</sup>M) and at 10<sup>-3</sup>M, at 0.55% NaCl tonicity did not differ significantly (P<0.05).<p align="justify"> This probably applied also to blood from malaria patients. The degree of hemolysis by quinine metabolite at concentration of 10<sup>-6</sup>M and 0.55% NaCl tonicity, was significantly higher relative to quinine (P<0.05) and at concentration of 10<sup>-2</sup>M the reverse was observed (P<0.01). At a concentration of 10<sup>-2</sup>m and 0.55% NaCl tonicity quinine as well as its metabolites apparently caused a higher degree of hemolysis in blood from malaria patients than in blood from healthy people.</p> |
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