ANALYSIS OF THE VACCINATION IMPACT AGAINST BASIC REPRODUCTIVE NUMBER AND OUTBREAK ON DENGUE HEMORRHAGIC FEVER

• Main Author: Aji Saputra, Yudha
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44325
• Institution: Institut Teknologi Bandung

In 2015 the World Health Organization (WHO) allows limited trial of vaccines as an effort to control dengue infection thoroughly. Before the vaccine is available for large scale application, it is necessary to do some study about the effectiveness of the vaccine. The main indicator being used in the epidemic modeling is the Basic Reproductive Number (R_0) which can be constructed analytically for simple dengue model. As an early indicator, R_0 does not describe the intensity of infection during the critical period of dengue infection. In this Final Project, in addition to seeing the effect of vaccination to R_0, it is also discussed the effect of vaccination to the outbreak, the peak time of the outbreak, and the effect of vaccination on a different initial state. The disease transmission model being used is the SEIR-SEI type with two age classes of the human population. The human population is divided into two age classes because vaccination is usually given to children. The effect of the vaccine against dengue infection is analyzed by simulating the dynamic of each compartment. Besides the reduction value of R_0 after administration of the vaccine, the increase of vaccination rate may decrease the peak of the outbreak, but increase the time of the outbreak. It is also shown that vaccination is more effective when the implementation is done at the early infection.