IDENTIFIKASI DAN PENANGANAN KEJADIAN REAKSI OBAT MERUGIKAN PADA PASIEN TUBERKULOSIS PARU YANG MENERIMA OBAT ANTITUBERKULOSIS LINI PERTAMA DI BALAI BESAR KESEHATAN PARU MASYARAKAT
Indonesia has become one of the three countries with the highest prevalence and incidence of tuberculosis (TB) globally. Based on previous research, the first-line treatment of antituberculosis drugs is associated with adverse drug reaction (ADR) which may affect TB treatment and its success, the...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/44385 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Indonesia has become one of the three countries with the highest prevalence and incidence of
tuberculosis (TB) globally. Based on previous research, the first-line treatment of antituberculosis
drugs is associated with adverse drug reaction (ADR) which may affect TB treatment and its
success, therefore proper management of ADR is important in supporting TB treatment. Previous
studies have also suggested that there are factors that significantly affect the tendency of ADR.
This research is an observational-retrospective study of pulmonary TB and pulmonary TB with
diabetes mellitus (DM) comorbidity patients who started first-line treatment of antituberculosis
drugs from January 2015 until August 2016 in Lung Health Center. This study aims to identify ADR
cases, its management and its success of the management, and also demographic and
pathological factors that affect the tendency of ADR. According to Naranjo algorithm, there are
183 symptoms categorized possible, probable, or definite ADR, which include 67 (36,61%)
symptoms of itching, 44 (24,04%) nausea and vomitting, 2 (1,09%) gastric pain, 4 (2,19%) loss of
appetite, 4 (2,19%) balance disorder, 3 (1,64%) tingling, 2 (1,09%) flu-like syndrome, 2 (1,09%)
hearing problem, 51 (27,87%) stiffness or joint pain, and 4 (2,19%) Drug Induced Hepatitis (DIH).
Management of itching, stiffness or joint pain, some cases of GI disturbances, and DIH have been
in accordance with the guideline, with the percentage of their successful management are 83%,
60%, 89%, and 100% respectively. Management of tingling has also been in accordance with the
guideline, but its successful management cannot be identified yet. According to chi-square
bivariate statistical analysis (95% CI), the tendency of stiffness or joint pain that related to
hyperuricemia is significantly affected by the increase of age, female gender, and DM comorbidity
(P=0,045, P=0,005, P=0,003).
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