KAJIAN POTENSI SILAN LIMBAH BATANG NANAS PADA PEMBENTUKAN PELET MENGANDUNG MESALAMIN UNTUK MEMODIFIKASI PELEPASANNYA SECARA IN VITRO

• Main Author: Rachel Praevina Nababan, Benita
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44558
• Institution: Institut Teknologi Bandung

Xylan, a main hemicellulose found in pineapple stem, can be used for colonic targeting of drug by ??ð?ð?ð?ã ???•??????£í•?•£?±?ð??ð?£?±????ã ?•?±?-insoluble, acidic resistant, and degraded only by xylanase enzyme present in colon. Mesalamine is an anti-inflammatory drug for inflammatory bowel diseases treatment. To study the potency of xylan in colonic targeting, xylan was used as a matrix and Kollicoat MAE 30DP as enteric coating material. Other excipients used to develop pellets was Avicel PH 101, cetyl alcohol, and PVP K-30. The pellet was prepared by extrusion followed by spheronization. The entire process was including dry mixing, wet granulation, extrusion, spheronizing and drying. The coating was subsequently applied on pellet by a simple immersion. Evaluations of noncoated and coated pellet included organoleptic observation, size distribution, flowability, bulk density, tapped density, compressiblity, friability, drug content, morphological analysis, in vitro release, and xylose detection as a result of enzymatic xylan degradation by xylanase of colonic microbes. Pellet formula containing 20% mesalamine, 40% xylan, 20% Avicel, 10% PVP, and 10% cetyl alcohol showed good physical characteristics. Pellets with a size range of 850 - 1000 ?????£?•?±­ ?ð?í ???????ð£?at MAE 30 DP maintained the physical characteristics. The release profile of coated pellet showed mesalamine release respectively 2.003% in HCl pH 1.2, 78.203% in phosphate buffer pH 6.8, and 95.923% in phosphate buffer at pH 7.4. While, without coating, the release of mesalamin was extremely high accounted of 98.7% in HCl pH 1.2 and completely release in phosphate buffer at pH 6.8. Although the coating step is able to retain the gastric release of mesalamine, improvement still must be developed to bring the mesalamine only in colonic compartment.