Synthesis and Characterization of Silica Nanoparticles as Carrier for Mangostin

• Main Author: Nitoayu Astari, Dwita
• Format: Final Project
• Language: Indonesia
• Subjects: Teknik (Rekayasa, enjinering dan kegiatan berkaitan)
• Online Access: https://digilib.itb.ac.id/gdl/view/44961
• Institution: Institut Teknologi Bandung

Mesoporous silica nanoparticle (MSN) as a carrier for mangosteen extract, a source of antioxidant, had been synthesized using Stober method. TEOS was used as a precursor for the MSN, to which hydrolysis and condensation reaction occurred during the synthesis. Chitosan and tapioca, due to its biocompatible, biodegradable, and non-toxic nature, are widely used in nanomedicine. One of the synthesized MSN had chitosan added to it, while the other had both chitosan and tapioca added to it. 2 percent chitosan were added to both solution, and one of the solution were also given 5 percent tapioca. Scanning Electron Microscope (SEM) result shows that the mean diameter of both silica were less than 200 nm, 138 nm for silica without tapioca and 134 nm for silica with tapioca. Mangostin of 1 % concentration and 25% concentration were entrapped to both silica separately. In both samples of silica, either with tapioca or without tapioca, Fourier Transform Infra Red (FTIR) results showed no difference in graphic profile between silica before entrapment and silica after entrapment of mangostin with 1 % concentration. FTIR results for silica after entrapment of mangostin with 25% showed new peaks at the profile which corresponded to C-H, C=O, C=C, O-H, and C-O-C chemical chain. UV – Vis test shows that peak absorbance of silica after entrapment of mangostin with 25% concentration are at 244 nm and 317 nm, which are the peak absorbance for ????-mangostin and ????-mangostin