AKTIVITAS ANTIHIPERLIPIDEMIA EKSTRAK ETANOL DAUN BAYAM MERAH (Amaranthus tricolor L.) DAN BIJI PICUNG (Pangium edule Reinw.) PADA TIKUS WISTAR JANTAN

• Main Author: Joceline Haury, Aurelia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44984
• Institution: Institut Teknologi Bandung

Cardiovascular disease is a main cause of mortality in the world, with the most important factor to cause it is hyperlipidemia. Hyperlipidemia occurs when feeding on high cholesterol food, so hyperlipidemic patients can be prevented using the right foodstuff. Red spinach and picung seed have been used empirically to treat hyperlipidemia. This research is aimed to test the activity and to determine the dose of both plant extracts for lowering blood lipid level. Test were conducted in hypercholesterolemic male Wistar rat models induced by administration of pure cholesterol, propylthiouracil, and high-cholesterol diet and against hypertriglyceridemic rat models induced by high-carbohydrate diet. In preventive and curative tests on hypercholesterolemic rat models, the two doses of red spinach (200 and 400 mg/kg bw) and picung seed extracts (216 and 432 mg/kg bw) can inhibit the increase of cholesterol level in preventive test and can decrease cholesterol levels significantly (p<0.05) in hypercholesterolemic rat models. In preventive test on hypertriglyceridemic rat models, only red spinach extract at a dose of 200 mg/kg bw and picung seed extract at a dose of 216 mg/kg bw prevented the increase of triglyceride levels significantly (p<0.05). However in the curative test, both doses of red spinach extract and picung seed extract can decrease the triglyceride level significantly (p<0.05). The two doses of picung seed extracts (200 and 400 mg/kg bw) decrease cholesterol level (60.7 and 54.9%) a little bit larger than that of the two doses of red spinach (51.4 and 57.9%). Picung seed extract also decreased triglyceride level (65.2 and 60.7%) better than red spinach extract (3.1 and 49.9%). On the lipoprotein index, the two doses of red spinach extract decreased lipoprotein index (70.0 and 83.1%), larger than those caused by the two doses of picung seed extract (36.7 and 38.0%). Through this experiment, it can be concluded that ethanolic extract of red spinach and picung seed are potential to be developed as herbal medicine for reducing and inhibiting the increase of blood lipids.