KAJIAN AKTIVITAS ANTIINFLAMASI DAN ANALGESIK JUS UMBI GEMBILI (DIOSCOREA ESCULENTA L. BURKILL) PADA RADANG KARAGENAN KAKI TIKUS WISTAR JANTAN

• Main Author: Hanifah, Diba
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/44985
• Institution: Institut Teknologi Bandung

Inflammation is a normal protective response to tissue injury. The non-steroidal antiinflammatory drug is one of choice in treating inflammation. However, these drugs have major side effect such as peptic ulcer. Umbi gembili (Dioscorea esculentaL. Burkill) is commonly utilized by people as a food. According to the previous research, umbi gembili (Dioscorea esculentaL. Burkill) showed activity as anti-inflammation. This study aims to investigate the anti-inflammatory effects on the umbi gembili (Dioscorea esculentaL. Burkill) juice and know the correlation between inflammation and pain. Umbi gembili (Dioscorea esculentaL. Burkill) juice was tested at a dose of 120 mg/kg bw, 235 mg/kg bw and 470 mg/kg bw in male Wistar rats. Inflammation was induced by injecting carrageenan 1% by intraplantar on a rat’s paw. Reference drugs and umbi gembili (Dioscorea esculentaL. Burkill) juice were given 30 minutes prior toinduction. Observations was made every hour for 6 hours after induction. In the antiinflammatory test, umbi gembili (Dioscorea esculentaL. Burkill) juice dose of 120 mg/kg bw was significantly different (p<0.1) compare to control group in the first hour with 38.88% percent edema; a dose of 235 mg/kg bw was significantly different (p<0.1) at 3 rd hour with percent edema 50.92%; and a dose of 470 mg/kg bb showed significant difference (p<0.1) on 1 st , 3 rd , 4 th hours with edema of 33.72%; 50.75%; 52; 97%, respectively. In the analgesic test, umbi gembili (Dioscorea esculentaL. Burkill) juice dose of 235 mg/kg bw was significantly different (p<0.1) at 1 st and 5 th hours with the percent reduction in pain threshold of -2.61% and -10.24%; a dose of 470 mg/kg bw was significantly different (p<0.1) on 1 st , 2 nd , 3 rd , 4 th , 5 th hours with the percent reduction in pain threshold - 18.96%; -25.10%; -26.10%; -24.41% and -17.51%.Umbi gembili (Dioscorea esculentaL. Burkill) juice at a dose of 470 mg/kg bw exhibit anti-inflammatory and analgesic effects markedly compared to control group. There was a negative correlation between edema and pain thresholdby using Pearson correlation test.