EFEK KARDIOPROTEKTIF EKSTRAK ETANOL RIMPANG JAHE MERAH (ZINGIBER OFFICINALE ROSCOE VAR. SUNTI VAL.) TERHADAP PROFIL SITOKIN PADA MODEL TIKUS ATEROSKLEROSIS DAN INFARK MIOKARD

• Main Author: Utami, Prima
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45220
• Institution: Institut Teknologi Bandung

In 2012, CVDs cause 17.5 million deaths in the world. An estimated 52% of the deaths are caused by coronary heart disease (CHD). Myocardial infarction is caused by vascular blockade due to atheroma plaque. Recent studies indicated the antihyperlipemic, antiinflammatory, and cardioprotective effect of sunti rhizome. Therefore sunti rhizome was hypothesized to affect the cytokines profile. This study aimed to evaluate the cardioprotective effect of sunti rhizome in atherosclerosis and isoproterenol-induced myocardial infarction rats through the serum lipids and cytokines profile. Male rats were induced by high cholesterol diets, pure cholesterol at dose of 100 mg/kg bw, cholic acid at dose of 200 mg/kg bw, and propylthiouracil (PTU) at dose of 12.5 mg/kg bw. At month 3, rats were treated with sunti rhizome ethanol extract at dose of 400 kg/kg orally and then the rats were induced by isoproterenol at dose of 150 mg/kg bw intraperitoneally at the end of month 3. Serum were collected at the beginning of experiment, then at the end of month 1, month 2, and month 3 for biochemical analysis. The administration of sunti rhizome ethanol extract at dose of 400 mg/kg bw showed significant differences (p<0.1) between dyslipidemia-infarctionsunti group and dyslipidemia-infarction group on triglyceride, AIP, and IL-10 level, and showed a significant difference between dyslipidemia-infarction-sunti group and dyslipidemia group on HDL level. This experiment showed that sunti rhizome etanol extract could reduce the level of triglyceride (40.40%) and atherogenic index plasma (27.46%), and could increase the level of IL-10 (80.36%) and HDL-C (39.33%). In conclusion, the administration of sunti rhizome etanol extract at dose of 400 mg/kg bw showed cardioprotective effect by reducing cardiovascular risk through increasing the HDL-C level and lowering the triglyceride level, and by increasing IL-10 level.