QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF 4-(PYRAZOL-4-YL)-PYRIMIDINE DERIVATIVES WHICH INHIBIT CYCLIN-DEPENDENT KINASE (CDK)2 AND CDK4/6
4-(Pyrazol-4-yl)-pyrimidine derivatives have anticancer activity by acting as inhibitor of cyclin-dependent kinase (CDK)1/2 and CDK4/6. CDK is a protein kinase which involved in controlling cell cycle, regulating transitions of one phase to another. Inhibition of CDK2 led to apoptosis, while inhi...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45377 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |