STUDI INTERAKSI INTERMOLEKULAR TRIMETOPRIM DAN SULFAMETOKSAZOL MENGGUNAKAN TEKNIK MULTIMEDIA BERBASIS METODE KRISTALOGRAFI
Combination between two or more active pharmaceutical ingredients are often used in pharmaceutical dosage form. This combination purpose is to improve its effect or even make the benefit more synergy. But this combination also has potential to create other problems in production, storage, and dis...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45384 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Combination between two or more active pharmaceutical ingredients are often used in
pharmaceutical dosage form. This combination purpose is to improve its effect or even make the
benefit more synergy. But this combination also has potential to create other problems in production,
storage, and distribution process which will affect to its using. It is caused by the existence of
intermolecular interaction between those active pharmaceutical ingredients, especially ingredient
which has similar crystal lattice. Based on that case, this research purpose is to identify the
intermolecular interaction which happened between sulfamethoxazole and trimethoprim and to
record the process of its intermolecular interaction on video through polarized microscopy. Initial
identification was done to both sulfamethoxazole and trimethoprim. Then the melting points of
physical mixture of trimethoprim-sulfametoxazole with some variation on its ratio was determined
using the hot stage method with polarized microscopy and capillary tube method with Electrothermal
IA9100. The determined result was used to make phase diagram. After that, the result from the phase
diagram was compared to the observation of contact method with polarized microscopy. The
observation was done by recording the intermolecular interaction process in polarized microscopy
using analytical software named camstudio. Based on observation, crystal habit of trimethoprim and
sulfamethoxazole is sferulit mosaic form and crystal habit of new molecular compound (cocriystal)
in contact zone was needle form. Based on phase diagram of trimethoprim-sulfamethoxale from
capillary tube method, it showed two eutectic points: in 0,1 mol fraction of trimetoprim with melting
point 161,3o C and in 0,6 mol fraction of trimethoprim with melting point 179o C. Based on hot stage
method, it showed two eutectic points: in 0,1 mol fraction of trimetoprim with melting point 159o C
and in 0,6 mol fraction of trimetoprim with melting point 166o C. The highest melting point of new
molecular compund from those two methods was in 0,5 mol fraction of trimethoprim. Based on
thermal profil from DSC, it showed the new molecular compound’s melting point was 171,2–187,7o
C. The video’s screen shoot of intermolecular interaction between trimethoprim and
sulfamethoxazole by contact method showed the recrystallization process from trimethoprim-
sulfamethoxazole and the formation of new molecular compound (cocrystal). Intermolecular
interaction that happened between trimethoprim–sulfamethoxazole, based on phase diagram from
capillary tube method, hot stage method, and DSC method, are the interaction of new molecular
compound forming which is signed by the existence of two eutectic points and the higher melting
point between two eutectic points which is new molecular compound’s melting point. The video of
intermolecular interaction between trimethoprim-sulfametoxazole was successfully made.
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