UPAYA PENINGKATAN LAJU DISOLUSI LOVASTATIN MENGGUNAKAN METODE DISPERSI PADAT DENGAN TEKNIK PELARUTAN-PELELEHAN MENGGUNAKAN PEMBAWA SENYAWA TURUNAN GULA!

• Main Author: Iffa Octafimi, Devina
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45403
• Institution: Institut Teknologi Bandung

Lovastatin is practically insoluble in water which is categorized as class 2 in the Biopharmaceutical Classification System. The substances that belong to this class has a characteristic of low solubility but high permeability. Hence the bioavailability of lovastatin is governed by its dissolution rate. One of the method that can be selected to improved the dissolution rate of drugs or active ingredients is by preparing solid dispersion. The aim of this study is to improve the dissolution rate of lovastatin by developing of solid dispersion using sugar derivate substance such as mannitol and isomalt as carriers. Solid dispersions with mannitol or isomalt carriers were performed using melting-solvent method, with ratio of 1:1 and 1:2 for each carrier. The dissolution test of pure lovastatin, its physical mixture and solid dispersion were carried out in surfactant buffer media of pH 7,0 using USP dissolution apparatus type 2 with rotation speed of 50 rpm. The physical characteristic of solid dispersion were evaluated using FTIR and SEM. The pure lovastatin and its solid dispersions were blended with excipiens and compressed into tablets by direct compression method. Then the dissolution test were performed for the tablet dosage form. The highest dissolution rate was showed by the solid dispersion of lovastatin in mannitol with ratio of 1:1 (99,27 ± 1,54 %). The infrared spectrum of the solid dispersion showed that the spectrum was a combination of lovastatin and manitol. Whereas the photomicrograph by SEM showed a particle size reduction in solid dispersion The dissolution test showed significant difference between dissolution rate from pure lovastatin tablets and its solid dispersion tablets in the media of phosphate buffer pH 7,0 containing 0,5% of surfactant.