FORMULASI KRIM MENGANDUNG EKSTRAK METANOL DAUN KERSEN (Muntingia calabura L.)

• Main Author: Cindy Cokrodiharjo, Felicia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45413
• Institution: Institut Teknologi Bandung

Itch or pruritus is an unpleasant sensation on skin that evokes the desire to scratch. Several factors, such as insects’s bite, exposure to pruritic agents, and allergy could stimulate itchy. Muntingia calabura L., which in Indonesian known as “daun kersen”has been used traditionally in Phillipines as an antipruritus. The purpose of this research was to prepare a cream containing daun kersen extract and evaluate its antipruritic effects. Formula of the cream was developed by optimizing the stiffening agent (cera alba and cetyl alcohol), emulsifying agents (tween80-span80, sodium CMC, stearic acid-TEA), and humectant (propylene glycol). Preparation process a larger amount of the cream was optimized by reducing the total oil content. Physical stability evaluation was perfomed by freeze-thaw and centrifugation tests. Antipruritic effect of the cream was evaluated in mice. The optimal formula of the cream based on physical stability results consisted of daun kersen extract 15%, cetyl alcohol 8%, combination of tween 80 and span 80 (5.7% : 4.3%) and propylene glycol 15%. Cream containing 15% methanol extract of Muntingia calabura L. leaf showed a significant decrease in the total number of scratch in mice following 20 minutes of the application. From this study we can conclude that the best cream formula consisted of methanol extract of Muntingia calabura L. leaf 15%, extra virgin olive oil 12%, cetyl alcohol 8%, propylene glycol 15%, tween 80 5.7%, span 80 4.3%, vitamin E 0.05%, methyl paraben 0.3%, propyl paraben 0.4%. Muntingia calabura L. leaf cream at concentration of 15% in mice has an antipruritic effect showed by a decrease in total number of scratch.