POLA RESISTENSI BAKTERI TERHADAP ANTIBIOTIK DI RUANG RAWAT JALAN SALAH SATU RUMAH SAKIT SWASTA DI BANDUNG

• Main Author: Pretty Megawaty, Haruhehe
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45534
• Institution: Institut Teknologi Bandung

The bacterial resistance is becoming a significant problem for Indonesia and the world. Because of some of antibiotics not sensitive to several specific bacteria, so that it causes long treated for patients, other infections that would be inflicted on patients, the cost becomes more expensive, and can lead to death. Improper use of antibiotics may be a causative factor of resistance. So we need a control system that performed resistance continuously, one of it is todocument thepatterns ofresistance. This study aimed to determine the pattern of bacterial resistance as the basis for rational antibiotic treatment, and determine the shift of bacterial resistance at a certain period statistically. The study used a retrospective observational design. Source data were obtained from the cultures reports and bacterial resistance reports consisting of specimens, bacteria that are present in the specimen, and the number of isolates of bacterium-sensitive in the period July- September 2013 to October-December 2014 in an outpatient room. Total specimen consist of 10 specimens, with the largest specimen types was urine (37.6%). Escherichia coli was contained the highest number on the specimen (33-55%). Bacteria with the highest prevalence of resistance in Gram-negative was Acinetobacter baumanii in each periode (with range 61-89%). Acinetobacter baumannii had been resistant with several first choices and alternatives antibiotics on four periods. And the highest prevalence of resistance in Gram-positive bacteria was Enterococcus faecalis (January-March and April-June 2014 with a range of 57-65.5%) and Staphylococcus haemolyticus (July-September 2013, and from October-December2014 with a range of 60-71%). Enterococcus faecalis resistant to alternative antibiotic only in period January to March, while Staphylococcus haemolyticus were resistant to alternative antibotic in the period from July to September 2013 and October-December 2014. There is a significant shift from sensitive to resistant at Staphylococcus epidermidis with antibiotics Erythromycin, Gentamycin, and Piperasilin Tazobaktam from the period January-March 2014 to July-September 2014 (x 2 calculate 25,49) and Acinetobacter baumanii with antibiotics Ciprofloxacin, Piperasillin Tazobaktam, and Tigecycline from the periode January-March 2014 to July-September 2014 (x 2 calculate ?). The largest specimen types was urine. Escherichia coli was contained the highest number on the specimen. Acinetobacter baumannii and Enterococcus faecalis are bacteria with the highest prevalence of resistance to first choices , alternatives, and test results for all periods.. And there is a significant shift at S.epidermidis and A.baumannii.