Adverse Drug Reactions Monitoring of First LineAntituberculosis Drug in Pulmonary and Extrapulmonary Tuberculosis Patients at Poliklinik DOTS RSUP Dr. Hasan Sadikin Bandung

• Main Author: Dera Putriranti, Resky
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45555
• Institution: Institut Teknologi Bandung

Indonesia is a country with a high burden of tuberculosis (TB). TB treatment is a long term therapy that use multiple drugs regimen (Fixed Dose Combination Drugs Antituberculosis), it makes high possibility of Adverse Drug Reactions (ADRs). There is a possibility of stopping the drug or noncompliance due to the rise in patients with ADRs. This study objective to identify adverse drug reactions (ADRs) of first-line anti-tuberculosis drugs, the incidence pattern of ADRs, the handling of the ROM, and its relationship with patient complian their pattern, management for the ADRs, and their effect to patient’s adherence. This study was a cross-sectional study conducted concurrently and retrospectively by interviewing the patient and medical personel and the medical record at Poliklinik DOTS RSUP Dr. Hasan Sadikin Bandung. The possibility of adverse drug reactions (ADRs) such as nausea with or without vomiting (41.75%), skin reactions (27.18%), joint pain (14.56%), dizziness (10.68%), DILI ( 4.85%), and impaired vision (0.97%). ADRs tend to be more common in patients (74.47%) than those who did not experience the ADRs (25.53%). Possible treatment for these ADRs were setirizin (14.29%), reintroduction and Setirizin (1.79%), reintroduction and kurkuma (8.93%), reintroduction, urea ointments and CTM (1.79%), permetrin and setirizin (3.57%), ketoconazole and loratadine (1.79%), salisylic acid lotion (1.79%), salisylic acid talc (1.79%), omeprazole (21.43%), antacids (4.65%), vitamin B6 (23.21%), paracetamol (3.57%), betahistine (7.14%), vitamin B complex (1.79%) and non-pharmacological (3.57%). Association of ADRs and patient’s compliance were conducted using chi-squared showed no significant correlation between ADRs and patient’s compliance. This could occur because of the possibility of the effectiveness of non compliance prevention that did by the health personel at Poliklinik DOTS RSUP Dr. Hasan Sadikin Bandung. ADRs in patients with tuberculosis was common and there was a relationship between the prevention of non compliance with reducing the number of non-compliance, drug withdrawal and the possibility of resistance.