THE DEVELOPMENT OF OCULAR FILM CONTAINED OFLOXACININ CHITOSAN MATRIX

• Main Author: Fauziah, Arsy
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45716
• Institution: Institut Teknologi Bandung

Chitosan is a natural polymer widely used in pharmaceutical application due to its biodegradability and biocompatibility characteristics. High molecular weight chitosan, which is commonly found in the market, is acid soluble and thus limits the application for some purposes, such as in ocular. The aim of this research was to improve the characteristics of a high MW chitosan ocular film by utilizinga water soluble, low MW chitosan modifier for delivery of ofloxacin in post-surgery. Various film formulas were prepared using a high MW chitosan as the main polymer matrix, glycerine and polyethilene glycol 400 as plasticizers and a low MW chitosan as film modifier. Glycerin was the best plasticizer that produced a good film appearance when added at 8.33 the weight of the high MW chitosan (TGc) and 6.25 times the weight of low and high MW chitosan blend at (1:1) ratio (MGb). The films were developed further respectively as TGcs and MGbs by cross-linked using sodium tripolyphosphateto control the release of ofloxacin and improve its mechanical characteristics. Water absorption capability, mechanical characteristics, thein vitro drug release, and anti-microbial activity were evaluated to select the film formula. The MGb formula showed the highest water absorption c.a 230%, while the lowest showed by the TGcs formula c.a 145%. On the contrary the TGcs formula had the highest film elasticity (141.33±8.81%) and the MGb formula had the lowest (42.55±6.11%).Surprisingly, the best control release of ofloxacin up to 24 hours was produced by the MGbs film, which also showed the highest antimicrobial activity. The MGbs also showed moderate film characteristics, which is suitable for ocular application. The research concluded that the addition of water soluble low MW chitosan and crosslinker agent can improve the control release and characteristics of chitosan based ocular film.