INCREASING SOLUBILITY AND DISSOLUTION OF GLIMEPIRIDE THROUGH CO-CRYSTALLIZATION METHOD
Co-crystallization of glimepiride (GMP) with oxalic acid (AO) and isonicotinamide (INA) had been done carried out grinding and solvent evaporation (acetone as a solvent) methods. Phase diagram of the binary system of GMP-AO and GMP-INA is used for initial identification of interaction between th...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45744 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Co-crystallization of glimepiride (GMP) with oxalic acid (AO) and
isonicotinamide (INA) had been done carried out grinding and solvent
evaporation (acetone as a solvent) methods. Phase diagram of the binary system of
GMP-AO and GMP-INA is used for initial identification of interaction between
the two component as well as reaffirmed by microscopic analysis using a heater
(hot stage) are associated with a polarization microscope. The solid phase was
characterized by thermal analysis method (Differential Scanning Calorymetry),
powder X-Ray diffractometry (Powder X-Ray Diffraction), infrared spectroscopy
(Fourier Transform-Infra Red) and microscopy ((Scanning Electron Microscope).
Solid state interaction between GMP-AO and GMP-INA at a molar ratio (3:7)
show a eutectic interaction at eutectical point each 130,7°C and 148,7°C. Next,
Test of solubility and dissolution rate using phosphate buffer pH 7,4 as a medium.
Solubility and dissolution rate of cocrystallization product of GMP increase
compared to physical mixture and its single compounds.
|
|---|