DEVELOPMENT OF O/W NANOEMULSION FORMULA OF SODIUM ASCORBYL PHOSPHATE FOR TRANSCUTANEOUS ROUTE

• Main Author: Rahma, Hanifa
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45948
• Institution: Institut Teknologi Bandung

Research on the development of anti-wrinkle active ingredients has been increasing to address the needs of aesthetic demand. One of the important anti wrinkle choosen is water soluble vitamin C derivative, sodium ascorbyl phosphate (NAP), having cells protection from free radicals and collagen inducer activity. The aim of this research was to increase NAP skin penetration by incorporating into oil globules of o/w nanoemulsion. Nanoemulsion was formulated using VCO as oil, Tween 80 as surfactant, and PEG 400 and glycerin admixture as a cosurfactant. Glycerin was also used to increase the solubility of NAP in oil phase. Nanoemulsion formulation was varied to produce a transparant –small globule size including the ratio of Tween 80, PEG 400, and Glycerin. Nanoemulsion was evaluated including freeze thaw, centrifugation test, physical appearance, and pH. The addition of 10% glycerin increased the solubility of NAP in oil phase. The optimum formula, contained of Tween 80, PEG 40, Glycerin, VCO, and buffer phosphat pH 6 of 17; 9; 10; 3; 61%, produced clear nanoemulsion at pH 6.5, stable dispersion with the globule size less than 200 nm. The penetration test using shed snake skin membrane results showed an increasing significantly the percentage of penetrated NAP (p<0,05) for 8 hours, which was from 26,46±2,81% (NAP water solution) to 63,48±4,02% (NAP nanoemulsion). These results are expected to contribute in the development of formula for enhancing NAP penetration into the skin so that the active ingredients can reach the target area in its proper place more effectively.