HYPERTENSION TREATMENT ON CHRONIC KIDNEY DISEASE PATIENTS AND THE EFFECT ON BLOOD PRESSURE, KIDNEY FUNCTION, AND QUALITY OF LIFE IN ONE OF PRIVATE HOSPITAL IN BANDUNG

• Main Author: Dwi Anggraini, Tyas
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/45951
• Institution: Institut Teknologi Bandung

Background and aim: Hypertension is not only a cause but also a complication for chronic kidney disease (CKD). CKD is a chronic condition that could impair quality of life. This study aims to assess the treatment ofhypertension with CKD in one of private hospital in Bandung and its effect to patient’s blood pressure, kidney function, and quality of life . Methode: This study was a concurrent observational analytical study examined data obtained from patient’s medical record, daily status in three months, and at the end of the third month we ask patient to fill questionnaire KDQOL-36. Result: The common combination antihypertensive use from the highest to the lowest are CCB-Clonidine (26,92%), CCB-Clonidine-ARB (21,15%), CCB-ACEI (15,38%), CCB-ARB (13,46%), ARB-diuretic loop and CCB-Clonidine-BB has the same percentage of use 11,54%. In combination of 2 antihypertensive CCB-Clonidine, CCB-ACEI, and CCB-ARB have no significance difference (p < 0,05) in reducing systolic blood pressure. CCB-Clonidine has the lowest ability in reducing serum creatinin and gives significance difference (p < 0,05) with CCB-ARB that has the greatest ability in reducing serum creatinin. In combination of 3 antihypertensive, the ability in reducing systolic blood pressure and serum creatinin effect between CCB-Clonidine-ARB and CCB-Clonidine-BB have no significance difference (p < 0,05). Antihypertensive treatment impact on quality of life score give significance difference (p < 0,05) in effect of kidney disease and mental domain (p < 0,05). In Health Related Quality of Life (HRQOL) parameter of combination of 2 antihypertensive therapy, CCB-Clonidine has the lowest score on effect of kidney disease domain and ACEI has the lowest score on mental domain. While in therapy combination of 3 antihypertensive therapy, CCB-Clonidine-BB has the lowest score in both domain. Conclusion: Combination CCB-ARB is the best option for combination of two antihypertensive, while CCB-Clonidine-ARB is the best option for combination of three antihypertensive. Both combination not only have the ability in reducing blood pressure but also reducing creatinin serum. Besides that both of them give a good score in quality of life domain that get the impact from antihypertensive therapy (effect of kidney disease domain and mental domain).