EFFECT OF CAPTOPRIL, LOSARTAN, AND AMLODIPINE TO A MODIFIED GOLDBLATT 2K1C RATS MODELLING
Background and Purposes: Diagnosis of a disease in medication has become an important matter in a determination of therapy that will be practiced to patient with renal failure condition. Captopril and losartan has become major choices of drug in hypertension patient with renal failure, but not in...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/45972 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Background and Purposes: Diagnosis of a disease in medication has become an
important matter in a determination of therapy that will be practiced to patient with renal
failure condition. Captopril and losartan has become major choices of drug in hypertension
patient with renal failure, but not intended to renal failure patient with renal arteri stenosis
condition. Application of those drugs can aggravate the renal condition in patient.
Amlodipine is a drug in calcium-cahannel blocker class, with high percentage of
application. Therefore the purpose of this study to compare effect of captopril, losartan,
and amlodipine on renal failure (stenosis) condition. Methods: Renal failure modelling
used in rats is a modified Goldblatt 2K1C modelling. Treatment given to left kidney is by a
modification of clip replacement with silk thread. There are five group of tested animal,
groups of negative control, positive control, groups of captopril, losartan, and amlodipine
drugs. Parameter measured are blood pressure, creatinine serum, kidney index organ,
macroscopic profile and kidney histology. Results: Blood pressure parameter indicates
that the three groups of drug are not significantly different, while compared to groups of
negative control they are dfferent, and at measurement point of 14
th
day and so on, the
three groups of drug show a significant difference compared to positive control group.
Creatinin serum parameter shows no significant difference at each of measurement point.
Left kidney (treated kidney) index organ parameter gives a significant difference between
negative control, captopril, and losartan group compared to negative control, and
amlodipine group. Conclusion: Either captopril, losartan, or amlodipin are able to decrease
the blood pressure in tested animals. Although, among that three groups of drug, the
histology profile and organ index results show that the worst damage occur to captopril
drug group.
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