SYNTHESIS OF CHALCONE FROM ACETOPHENONE AND BENZALDEHYDE DERIVATIVES IN 1-OCTYL-3-METHYLIMIDAZOLIUM BROMIDE IONIC LIQUID MEDIUM UTILIZING MICROWAVE ASSISTED ORGANIC SYNTHESIS (MAOS) METHOD

• Main Author: Dani Sirait, Muhammad
• Format: Final Project
• Language: Indonesia
• Subjects: Kimia
• Online Access: https://digilib.itb.ac.id/gdl/view/47528
• Institution: Institut Teknologi Bandung

Chalcone is a flavonoid derivative compound containing ?,?-unsaturated carbonyl framework. Chalcone has some important bioactivities, such as anti-oxidant, anti-inflammatory, anticancer, fluorecent material, antidiabetic and antiviral agent. In this study, chalcone derivatives were synthesized using solvents that met the principles of green chemistry, which is ionic liquids 1-octyl-3-methylimidazolium bromide ([OMIm]Br) utilizing MAOS (Microwave-Assisted Organic Synthesis) method. This method has several advantages, such as short reaction time, simple working procedures, high yields of product and environment friendly. 1-Octyl-3-methylimidazolium bromide was successfully synthesized under microwave irradiation conditions at power of 300 Watts and temperature of 50 °C for 60 minutes producing 50% yields of product. In this study, four chalcone compounds: 2,2'- dihydroxychalcone, 2,2'-dihydroxy-3-methoxychalcone, 2-hydroxychalcone, and 2-hydroxy- 3-methoxychalcone were successfully synthesized with the yields of 60%, 70%, 72%, and 82%, respectively. The synthesis of chalchones was performed in ionic liquid médium (1% (w/v) [OMIm]Br) utilizing MAOS method at 80 °C and irradiation power of 300 Watts for 10 minutes. The confirmation of the structure of the synthesized chalcones was carried out using 1H NMR (500 MHz) and 13C NMR (125 MHz) spectroscopy.