THE EFFECT OF DIMER ADDITION ON HYDRATED HER2 PROTEIN MODEL USING COARSE-GRAINED AND FREE ENERGY PERTURBATION METHODS
Approximately 15 to 25% of breast cancer occurred by HER2 overexpression. HER2 is protein located in cell surface as signal pathway and active in dimer formation. Unlike HER1, HER3, and HER4 whose activity is ligand-dependent, HER2 is ligand-independent. This study performs molecular dynamics simula...
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| Format: | Final Project |
| Language: | Indonesia |
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| Online Access: | https://digilib.itb.ac.id/gdl/view/47567 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
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