RELATIONSHIP BETWEEN TRANSITION MONOID AND MINIMAL STATE AUTOMATON TO IDENTIFY GENETIC MUTATIONS ON ,B-GLOBIN GENE IN THALASSEMIA DISEASE
/)-Thalassemia is an autosomal recessive blood disorder characterized by abnor malities in the synthesis of the /) globin gene. Together with a globin gene, /) globin gene is a subunit of globin protein, called Haemoglobin, located inside our red blood cells to deliver oxygen from the lungs t...
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| Main Author: | |
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/47737 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | /)-Thalassemia is an autosomal recessive blood disorder characterized by abnor malities in the
synthesis of the /) globin gene. Together with a globin gene, /) globin gene is a subunit of globin
protein, called Haemoglobin, located inside our red blood cells to deliver oxygen from the lungs to
all of the tissues throughout our body. Thereby, individuals with /)-Thalassemia will often feel
limp due to a lack of oxygen dissolved in their blood. 1n this Final Project, I have constructed a
finite state automaton to detect and clasify /) globin-gene mutation using its DNA sequence. Finite
state automata have a close connection to an algebraic structure, that is a monoid. Together with
the theory of syntactic monoid, I presents a method ology to minimize the numbers of the internal
state of an automaton to have minimal automata. So that we can construct a minimal automaton to
detect /) globin-gene mutation causing /)-Thalassemia disease. 1n the end, I have developed a
Matlab program to simulate it.
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