FORMULASI DAN EVALUASI NANOEMULSI TEA TREE (MELALEUCA ALTERNIFOLIA) OIL SERTA STUDI LITERATUR UJI ANTI BAKTERI

• Main Author: Anabella Dwiputri, Stefani
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/48611
• Institution: Institut Teknologi Bandung

Tea tree oil is an essential oil obtained from Melaleuca alternifolia that has been use as topical because its effect such as antimicrobial. To improve its activity, tea tree oil is formulated in nanoemulsion dosage form. This study aimed to evaluate the tea tree oil nanoemulsion formulation. Optimization of tea tree oil nanoemulsion formulation was done by using surfactans (Tween 80, Cremophor RH 40), co-surfactans (PEG 400, glycerin), and water. Nanoemulsion was prepared using sonication method. Nanoemulsion tea tree oil was optimally done by using Tween 80 15% (b/b), Glycerin 10% (b/b), tea tree oil 5% (b/b), dan water 70% (b/b). The nanoemulsion had clear and light yellow appearance with distinctive smell of tea tree oil; globular size was 22,8 ± 5,26 nm; polydispersity index was 0,31 ± 0,08; and pH 5,4. The tea tree oil nanoemulsion showed a stable physical appearance over 21 days weeks of storage at low temperature (4°C), room temperature (25°C), high temperature (40°C), and cycling test.