EVALUASI EFEK TERATOGENIK KOMBINASI EKSTRAK AIR DAUN TEMPUYUNG (SONCHUS ARVENSIS L.) DAN DAUN BINAHONG (ANREDERA CORDIFOLIA (TEN.) STEENIS) PADA TIKUS WISTAR

• Main Author: Kasih Mentari, Sinar
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/48620
• Institution: Institut Teknologi Bandung

Water extract of tempuyung (Sonchus arvensis L.) and madeira vine (Anredera cordifolia (Ten.) Steenis) leaves as combination has been proven for its antihipertention activity but there is no information related to its safety for pregnant woman yet. This experiment was done to evaluate teratogenic effect of water extract of tempuyung and madeira vine leaves in combination at dosage 100 mg/kgBW, 400 mg/kg BW, and 1000 mg/kg BW for Wistar rat. Extract was made as suspension in Na-CMC 0,5% and given orally to pregnant rat on gestation day 6-15 as much as 1 mL/100 gram BW. Pregnant rat sacrificed at gestation day 20. All parameters related to fetus included amount of fetus, fetus weight, skeletal and organ condition were evaluated. Abnormal skeletal and organ percentage for each dosage group was compared to normal group and analyzed with One Way Annova method. There was no significant difference of both average amount and weight of fetus from all dosage groups compared to control group (p>0,05). There was no skeletal dan organ abnormality found in all groups so that water extract of tempuyung and binahong leaves in combination at dosage 100 mg/kgBW, 400 mg/kg BW, and 1000 mg/kg BW showed no teratogenic effect but contraindicated for pregnant women and who is planning for having baby due to founding of undeveloped fetus