AKTIVITAS LAKSATIF EKSTRAK ETANOL DAUN BUNGA MERAK [CAESALPINIA PULCHERRIMA (L.) SWARTZ] DAN BUAH ASAM JAWA [TAMARINDUS INDICA (L.)] PADA MENCIT SWISS WEBSTER

• Main Author: Ruth Serenia, Ireina
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/48632
• Institution: Institut Teknologi Bandung

Constipation is one of the intestinal obstruction that can cause defecation difficulty and inconvenience. Laxative is a compound which can stimulate intestinal peristaltic, especially colon, propulsion, regulate water absorption in colon, and soften the faeces so the condition of constipation can be handled. Peacock flower [Caesalpinia pulcherrima (L.) Swartz.] leaves and tamarind [Tamarindus indica (L.)] fruit pulp belongs to Fabaceae plant that traditionally used as laxative. The aim of this research is to determine laxative activity of ethanolic extract of peacock flower leaves and water-ethanol extract of tamarind fruit pulp in Swiss Webster mice. This research begins with the orientation of the formation of constipation conditions in mice followed by a laxative activity test. As a constipation inducer cold saline is given intragastrically. Based on the reduction in the number of stools, wet stool weight, dry stool weight, and the difference in wet and dry stool weight, the condition of constipation is formed after administration of cold saline for 21 days. In the laxative test, the amount of stool increased significantly (p<0.05) in a single administration of tamarind fruit pulp extract of 800 mg/kg bw (from 0.60±0.89 under constipation to 4.6±1.82) and at a dose of 1.6 g/kg bw (from 1.0±0.71 to 4.8±0.84) and Peacock flower leaves extract at 150 mg/kg bw (2.4±1.14 to 5.0±2.12). The two doses of tamarind fruit pulp extract can also significantly (p<0.05) increase the weight of stools namely from 0.134±0.198 to 0.408±0.161 at a dose of 800 mg/kg bw and from 0.204±0.153 to 0.440±0.069 at dose of 1.6 g/kg bw. Further readministration of the two extracts up to 7 days showed all test parameters were up. Based on the result of this study, it can be concluded that the two extract i.e. tamarind fruit pulp and Peacock flower leaves extract tested have laxative properties. Tamarind fruit pulp extract is more efficacious as a laxative compared to Peacock Flower.