ANALYSIS OF CHEMOTHERAPY ADVERSE DRUG REACTIONS AND QUALITY OF LIFE IN NON-HODGKIN LYMPHOMA’S PATIENTS IN DR. HASAN SADIKIN HOSPITAL

• Main Author: Dyah Utami, Milati
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/48729
• Institution: Institut Teknologi Bandung

Non-Hodgkin lymphoma is the tenth highest cancer in Indonesia, both in terms of incidence and mortality. Chemotherapy is very effective first line therapy for non- Hodgkin lymphoma, but it can cause adverse drug reactions (ADRs). ADRs also affects the quality of life of patients which generally decrease due to chemotherapy. The aim of the study was analyzing the probability and the level of severity of ADRs, also measuring the quality of life of patients. This study was descriptive observasional that used cross sectional design and performed prospectively on 68 patients with chemotherapy of non-Hodgkin lymphoma in Asnawati ward of Dr. Hasan Sadikin Hospital during January-March 2020. The data was analyzed descriptively to determine the probability and the level of severity of ADRs, using Naranjo scale and Hartwig-Siegel scale respectively. Quality of life was measured using the EORTC QLQ-C30 questionnaire. The analysis showed that ADRs had probability of 78% “probable”and 22% “highly probable”. While the level of severity of 67,6% ADRs was level 3 and the remaining 32,4% ADRs was level 4b. Most common ADRs occurred in females which were alopecia, weakness, fatigue, pain, nausea, lacked appetite, and peripheral neuropathy. The result of the measurement of quality of life showed that females had lower quality of life than males on all three scales, except for symptom of short of breath and financial difficulties. Young adult males had better global health status and functional scale, while middle age males had worse symptoms scale. Middle age females had better global health status and functional scales, while older age females had worse symptoms scale.